XDOM, a graphical tool to analyse domain arrangements
in any set of protein sequences
CABIOS Vol. 13 no 6 1997 pages 601-608
GOUZY J.1, EUGENE P. 1, GREENE E.A. 1, KAHN D. 1 and CORPET F. 2*
2Laboratoire de Génétique Cellulaire,
Running title: Graphical tool for domain families.
Motivation: To extract the maximal possible information from a set of protein sequences, its modular organisation must be known and clearly displayed. This is important both for structural and functional analysis.
Results: The paper presents an algorithm and a graphical interface called xdom which performs a systematic analysis of the modular organisation of any set of protein sequences. The algorithm is an automatic method to identify putative domains from sequence comparisons. The graphical tool displays the proteins as a set of linked boxes, corresponding to its domains. The method has been tested on a family of bacterial proteins and on whole genomes. It is currently applied to the complete swiss-prot database to build the ProDom database.
Availability: xdom is available free of charge by anonymous ftp. The ProDom database can be consulted here .